βWhat does Paul mean when he says that he was the minister of Jesus Christ to the Gentiles βthat the offering up of the Gentiles might be acceptable, being sanctified by the Holy Ghost (Rom. 15:16)?β
Under the Law, the GentilesΒ couldnβtΒ offer themselves up as an offering that would be βacceptableβ unto God as Paul tells us to do (Rom. 12:1,2). But now we are βsanctifiedβ orΒ set apart to GodΒ by the Holy Spiritβthat is, by theΒ WordΒ of the Spirit, the words the Spirit teachesΒ in His WordΒ (1 Cor. 2:13). In HisΒ rightly dividedΒ Word, He teaches in Paulβs epistles that the grace of God is now available to Gentiles as well as to Jews. Paul told the Ephesian elders,
ββ¦the word of His graceβ¦is able to build you up,Β and to give you an inheritance among all them which are sanctifiedβ (Acts 20:32).
See the connection? The Jews were sanctified, and so their sacrifices were acceptable to God, and nowΒ we tooΒ are sanctified by βthe word of His graceβ that the Spirit presents in His Word through the Apostle Paul.
So when the Macedonians βgave their own selves to the Lord,β they were able to do this βby the will of Godβ (2 Cor. 8:5). They couldnβt have done that under the Law, for God wouldnβt have accepted their offering. But under grace, βthe offering up of the Gentilesβ is βacceptable, being sanctified by the Holy Ghost.β source