Sin:Β When Cain failed to bring the acceptable blood sacrifice that God required, βhis countenance fell.β He descended into a state of depression due to his disobedience. The Lord confronted Cain to do what was right! In other words, bring the proper sacrifice and he would be accepted, but if he refused to do so, βsin lieth at the door,β (Genesis 4:7) that is, crouching at the door to consume him with guilt. Disobedience and unaddressed sin in a life can be one of the causes of depression.
Satanic Attack:Β After Elijahβs incredible triumph at Mt. Carmel over the prophets of Baal, Jezebel vowed to hunt him down and kill him. Since this was no idle threat, Elijah fled for his life. On the lam, he sat down under a juniper tree and descended into a dark place called depression (1 Kings 19:5). Oftentimes after we experience a great victory for the Lord, Satan will cause a shadow of melancholy to come over us. Many of the past giants of the faith, who made major inroads into the kingdom of darkness, were afflicted with bouts of depression.
Medical:Β Sometimes depression is a medical condition, which can be caused by any number of reasons: biological differences, brain chemistry (neurotransmitters interaction with neurocircuits), hormones, family history, etc. If you suffer with clinical depression, it should not be taken lightly. Consult your family doctor as soon as possible. There are many very effective medications today that can help you live a normal life. source
